Livewired: The Inside Story of the Ever-Changing Brain | David Eagleman

"Eagleman renders the secrets of the brain’s adaptability into a truly compelling page-turner.” —Khaled Hosseini, author of The Kite Runner

“Livewired reads wonderfully like what a book would be if it were written by Oliver Sacks and William Gibson, sitting on Carl Sagan’s front lawn.” —The Wall Street Journal

What does drug withdrawal have in common with a broken heart? Why is the enemy of memory not time but other memories? How can a blind person learn to see with her tongue, or a deaf person learn to hear with his skin? Why did many people in the 1980s mistakenly perceive book pages to be slightly red in color? Why is the world’s best archer armless? Might we someday control a robot with our thoughts, just as we do our fingers and toes? Why do we dream at night, and what does that have to do with the rotation of the Earth?
 
The answers to these questions are right behind our eyes. The greatest technology we have ever discovered on our planet is the three-pound organ carried in the vault of the skull. This book is not simply about what the brain is; it is about what it does. The magic of the brain is not found in the parts it’s made of but in the way those parts unceasingly reweave themselves in an electric, living fabric.

In Livewired, you will surf the leading edge of neuroscience atop the anecdotes and metaphors that have made David Eagleman one of the best scientific translators of our generation. Covering decades of research to the present day, Livewired also presents new discoveries from Eagleman’s own laboratory, from synesthesia to dreaming to wearable neurotech devices that revolutionize how we think about the senses.

Editorial Reviews

Review

"Masterful . . . Outstanding popular science."⁠—Kirkus Reviews (starred)

"An altogether fascinating tour of the astonishing plasticity and interconnectedness inside the cranial cradle of all of our experience of reality, animated by Eagleman’s erudite enthusiasm for his subject, aglow with the ecstasy of sensemaking that comes when the seemingly unconnected snaps into a consummate totality of understanding."—Maria Popova, Brain Pickings

"Vivid . . . Since the passing of Isaac Asimov, we haven’t had a working scientist like Mr. Eagleman, who engages his ideas in such a variety of modes. Livewired reads wonderfully like what a book would be if it were written by Oliver Sacks and William Gibson, sitting on Carl Sagan’s front lawn."—Wall Street Journal

"Delivers an intellectually exhilarating look at neuroplasticity . . . Eagleman’s skill as teacher, bold vision, and command of current research will make this superb work a curious reader’s delight."—Publishers Weekly (starred)

"David Eagleman, the Jolly Sherlock Holmes of neuroscience, makes me believe that the universe of possibility required to create utopia is already housed in each of our brains. His knowledge and enthusiasm are intoxicating. His book demonstrates the principle about which he is writing; my mind has been changed by his words."—Russell Brand, Comedian & Activist

"There is much to extract from this fascinating work, that is recommended for readers interested in neuroscience, technology, and the intersection of the two."—Library Journal (starred) 

"The pages of Livewired are chockfull of mind bending ideas and dazzling insights. Eagleman's infectious enthusiasm, his use of fascinating anecdotes, and his clear, effortless prose render the secrets of the brain’s adaptability into a truly compelling page-turner. Livewired is a fun and whirlwind exploration of the most complex thing in the universe."—Khaled Hosseini, author of The Kite Runner

"Eagleman brings the subject to life in a way I haven’t seen other writers achieve before.”—Clare Wilson, New Scientist

About the Author

Dr. DAVID EAGLEMAN is a neuroscientist and internationally best-selling author. He teaches brain plasticity at Stanford University, is the cre­ator and host of the Emmy-nominated television series The Brain, and is the CEO of Neosensory, a company that builds the next generation of neuroscience hardware. The author of seven previous books, Eagleman lives in Silicon Valley in California.
 

Excerpt. © Reprinted by permission. All rights reserved.

1

THE DELICATE PINK MAGISTERIUM
 
Imagine this: instead of sending a four-hundred-pound rover vehicle to Mars, we merely shoot over to the planet a single sphere, one that can fit on the end of a pin. Using energy from sources around it, the sphere divides itself into a diversified army of similar spheres. The spheres hang on to each other and sprout features: wheels, lenses, temperature sensors, and a full internal guidance system. You’d be gobsmacked to watch such a system discharge itself.
 
But you only need to go to any nursery to see this unpacking in action. You’ll see wailing babies who began as a single, microscopic, fertilized egg and are now in the process of emancipating themselves into enormous humans, replete with photon detectors, multi-jointed appendages, pressure sensors, blood pumps, and machinery for metabolizing power from all around them.
 
But this isn’t even the best part about humans; there’s something more astonishing. Our machinery isn’t fully preprogrammed, but instead shapes itself by interacting with the world. As we grow, we constantly rewrite our brain’s circuitry to tackle challenges, leverage opportunities, and understand the social structures around us.
 
Our species has successfully taken over every corner of the globe because we represent the highest expression of a trick that Mother Nature discovered: don’t entirely pre-script the brain; instead, just set it up with the basic building blocks and get it into the world. The bawling baby eventually stops crying, looks around, and absorbs the world around it. It molds itself to the surroundings. It soaks up everything from local language to broader culture to global politics. It carries forward the beliefs and biases of those who raise it. Every fond memory it possesses, every lesson it learns, every drop of information it drinks—all these fashion its circuits to develop something that was never preplanned, but instead reflects the world around it.
 
This book will show how our brains incessantly reconfigure their own wiring, and what that means for our lives and our futures. Along the way, we’ll find our story illuminated by many questions: Why did people in the 1980s (and only in the 1980s) see book pages as slightly red? Why is the world’s best archer armless? Why do we dream each night, and what does that have to do with the rotation of the planet? What does drug withdrawal have in common with a broken heart? Why is the enemy of memory not time but other memories? How can a blind person learn to see with her tongue or a deaf person learn to hear with his skin? Might we someday be able to read the rough details of someone’s life from the microscopic structure etched in their forest of brain cells?
 
THE CHILD WITH HALF A BRAIN
 
While Valerie S. was getting ready for work, her three-year-old son, Matthew, collapsed on the floor. He was unarousable. His lips turned blue.
 
Valerie called her husband in a panic. “Why are you calling me?” he bellowed. “Call the doctor!”
 
A trip to the emergency room was followed by a long aftermath of appointments. The pediatrician recommended Matthew have his heart checked. The cardiologist outfitted him with a heart monitor, which Matthew kept unplugging. All the visits surfaced nothing in particular. The scare was a one-off event.
 
Or so they thought. A month later, while he was eating, Matthew’s face took on a strange expression. His eyes became intense, his right arm stiffened and straightened up above his head, and he remained unresponsive for about a minute. Again Valerie rushed him to the doctors; again there was no clear diagnosis.
 
Then it happened again the next day.
 
A neurologist hooked up Matthew with a cap of electrodes to measure his brain activity, and that’s when he found the telltale signs of epilepsy. Matthew was put on seizure medications.
 
The medications helped, but not for long. Soon Matthew was having a series of intractable seizures, separated from one another first by an hour, then by forty-five minutes, then by thirty minutes—like the shortening durations between a woman’s contractions during labor. After a time he was suffering a seizure every two minutes. Valerie and her husband, Jim, hurried Matthew to the hospital each time such a series began, and he’d be housed there for days to weeks. After several stints of this routine, they would wait until his “contractions” had reached the twenty-minute mark and then call ahead to the hospital, climb in the car, and get Matthew something to eat at McDonald’s on the way there.
 
Matthew, meanwhile, labored to enjoy life between seizures.
 
The family checked into the hospital ten times each year. This routine continued for three years. Valerie and Jim began to mourn the loss of their healthy child—not because he was going to die, but because he was no longer going to live a normal life. They went through anger and denial. Their normal changed. Finally, during a three-week hospital stay, the neurologists had to allow that this problem was bigger than they knew how to handle at the local hospital.
 
So the family took an air ambulance flight from their home in Albuquerque, New Mexico, to Johns Hopkins hospital in Baltimore. It was here, in the pediatric intensive care unit, that they came to understand that Matthew had Rasmussen’s encephalitis, a rare, chronic inflammatory disease. The problem with the disease is that it affects not just a small bit of the brain but an entire half. Valerie and Jim explored their options and were alarmed to learn there was only one known treatment for Matthew’s condition: a hemispherectomy, or the surgical removal of an entire half of the brain. “I can’t tell you anything the doctors said after that,” Valerie told me. “One just shuts down, like everyone’s talking a foreign language.”
 
Valerie and Jim tried other approaches, but they proved fruitless. When Valerie called Johns Hopkins hospital to schedule the hemispherectomy some months later, the doctor asked her, “Are you sure?”
 
“Yes,” she said.
 
“Can you look in the mirror every day and know you’ve chosen what you’ve needed to do?”
 
Valerie and Jim couldn’t sleep beneath the crushing anxiety. Could Matthew survive the surgery? Was it even possible to live with half of the brain missing? And even if so, would the removal of one hemisphere be so debilitating as to offer Matthew a life on terms not worth taking?
 
But there were no more options. A normal life couldn’t be lived in the shadow of multiple seizures each day. They found themselves weighing Matthew’s assured disadvantages against an uncertain surgical outcome.
 
Matthew’s parents flew him to the hospital in Baltimore. Under a small child-sized mask, Matthew drifted away into the anesthesia. A blade carefully opened a slit in his shaved scalp. A bone drill cut a circular burr hole in his skull.
 
Working patiently over the course of several hours, the surgeon removed half of the delicate pink material that underpinned Matthew’s intellect, emotion, language, sense of humor, fears, and loves. The extracted brain tissue, useless outside its biological milieu, was banked in small containers. The empty half of Matthew’s skull slowly filled up with cerebrospinal fluid, appearing in neuroimaging as a black void. In the recovery room, his parents drank hospital coffee and waited for Matthew to open his eyes. What would their son be like now? Who would he be with only half a brain?